Fish collagenase

Keratoconus experimentally produced in mice using collagenase

Introduction: Keratoconus is a relatively common disease of cornea in which structural changes within the cornea cause it to thin and change to a conical shape and scar at the central portion of cornea. So far, few methods and drug treatments were introduced due to both lack of accepted animal models to induce experimental keratoconus and limitation of research in human considering ethical issu...

Corynebacterium rathayil bacterial collagenase

Athanasios YIOTAKIS,* Alain LECOQ,t Anna NICOLAOU,* Jean LABADIEt and Vincent DIVEt§ TDepartment of Organic Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 15771, Greece, tDepartement d'lng6nierie et d'Etudes des Prot6ines, D.S.V., C.E.A. CE-Saclay, 91191 Gif/Yvette, Cedex, France, and tStation de Recherches sur la Viande, INRA de Theix, 631...

Collagen and Collagenase

That rheumatic fever generally attacks children and rheumatoid arthritis usually occurs in adults may be due to an alteration in the target organ (collagen plus ground substance) with age. Perhaps young, growing collagen is more susceptible to the stimuli producing rheumatic fever, whilst the more metabolically inert adult collagen responds with rheumatoid change to factors as yet unknown. One ...

Collagenase in scleroderma.

Collagenase activity was measured by direct assay in skins from 12 patients afflicted with systemic sclerosis. In seven of those cases where extensive involvement of the forearm and trunk skin existed, collagenase activity of the involved skin was minimal or absent. Moreover, in the same patient, regions of marked skin involvement (e.g., forearm) showed no collagenase activity, when clinically ...

Inhibitors of Bacterial Collagenase